Fisetin is a polyphenol found in fruits such as strawberries (160 mg/kg), apples (27mg/kg) and persimmon (10 mg/kg), as well as in some medicinal plants. It has multiple biological benefits, including the inhibition of cell proliferation, neuroprotection, bone protection and suppression of inflammation.
But it’s two most extraordinary properties are its ability to both destroy senescent cells that pervade the body and aid in activating autophagy, which enables cells to devour their own waste products. Several studies have shown it helps extend longevity and reduce markers of senescence in humans.
Its hydrophobic nature means it easily penetrates cells via the cell membrane. It then encourages the self-destruction of abnormal cells (such as senescent cells) by activating various characteristic proteins.
One of its main advantages over other senolytics is its ability to reduce the proportion of senescent immune cells (T lymphocytes and NK cells). Since immune cells are themselves important for cleaning out senescent cells, this makes fisetin even more effective. This study highlights its senolytic properties and impact on longevity: Fisetin is a senotherapeutic that extends health and lifespan.
FISETIN 300 mg (60 Capsules)
Fisetin is a rare product that acts on three key processes associated with aging: the increase in senescent cells, inactivation of the autophagy process, and the decline in neural communication. People looking to combat the aging process often turn to fisetin due to its well documented advantages.